Annotated protein:	Receptor-type tyrosine-protein phosphatase delta (Protein-tyrosine phosphatase delta) (R-PTP-delta) (EC 3.1.3.48). Gene symbol: PTPRD. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q64487
antibody wiki:	search antibodypedia...
SynGO gene info:	SynGO data @ PTPRD
Ontology domain:	Cellular Component
SynGO term:	integral component of presynaptic membrane (GO:0099056)
Synapse type(s):	retina, glutamatergic
Annotated paper:	Farhy-Tselnicker I, et al. "Astrocyte-Secreted Glypican 4 Regulates Release of Neuronal Pentraxin 1 from Axons to Induce Functional Synapse Formation" Neuron. 2017 Oct 11;96(2):428-445.e13 PMID:29024665
Figure(s):	fig 7B, 7K
Annotation description:	PTPRD was present in neurons of the visual system during development and is localized to presynaptic terminals. 26/01/2018 Pim - Literal: "To determine whether RPTPδ is present in presynaptic terminals of RGC and dLGN neurons in vivo, we carried out immunostaining at P6 in the SC and VC, respectively, against VGlut2 and RPTPδ and observed punctate staining for RPTPδ that colocalized with VGlut2 (Figures 7B and 7K, top). Thus, RPTPδ is present in neurons of the visual system during development and is localized to presynaptic terminals, placing it in the right place at the right time to mediate Gpc4-induced release of NP1." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Confocal
Annotator(s):	Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:	Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:	2248
Dataset release (version):	20231201
View annotation as GO-CAM model: