| Annotated protein: | Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) (Leukocyte common antigen related) (LAR). Gene symbol: PTPRF. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64604 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRF |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Dunah AW, et al. "LAR receptor protein tyrosine phosphatases in the development and maintenance of excitatory synapses" Nat Neurosci. 2005 Apr;8(4):458-67 PMID:15750591 |
| Figure(s): | Fig 1E, 1F, Supplementary Fig. 1 |
| Annotation description: | PTPRF was enriched in postsynaptic density fractions. 15/01/2018 Pim - Supplementary Fig. 1: "The percentage of LAR clusters that colocalized with PSD-95 clusters was 54.1 ± 4.8% (DIV21) and 21.2 ± 2.4% (DIV7); the percentage that colocalized with bassoon was 52.8 ± 4.3%" ... "The immunocytochemical data and biochemical findings are consistent with LAR-RPTP being enriched at excitatory synapses but more widely distributed in neurons than PSD-95." - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2247 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |