| Annotated protein: | Receptor-type tyrosine-protein phosphatase S (R-PTP-S) (EC 3.1.3.48) (Leukocyte common antigen-related protein-tyrosine phosphatase 2) (LAR-PTP2) (Receptor-type tyrosine-protein phosphatase sigma) (R-PTP-sigma). Gene symbol: PTPRS. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q64605 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PTPRS |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of presynaptic membrane (GO:0099056) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Takahashi H, et al. "Postsynaptic TrkC and presynaptic PTPsigma function as a bidirectional excitatory synaptic organizing complex" Neuron. 2011 Jan 27;69(2):287-303 PMID:21262467 |
| Figure(s): | fig 3E, 3F, 3J |
| Annotation description: | - PTPRS immunoreactivity was present in a punctate pattern decorating the dendrites of cultured hippocampal neurons at DIV 15 and these puncta overlapped with VGLUT1, but not with VGAT. - Furthermore, PTPRS puncta were apposed to PSD-95 puncta in brain in hippocampal CA1 region. 15/01/2018 Pim - Literal: "PTPσ immunoreactivity was also present in a punctate pattern decorating the dendrites of cultured hippocampal neurons at DIV 15, and these puncta overlapped with VGLUT1 (Figure 3E). PTPσ puncta overlapping VGLUT1 were also observed on axons not contacting dendrites, suggesting an axonal localization (Figure 3E, arrowheads).' - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2246 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |