| Annotated protein: | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle). Gene symbol: MYO5A. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99104 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5A |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic cytosolic calcium levels (GO:0099566) |
| Synapse type(s): | cerebellum, glutamatergic |
| Annotated paper: | Wagner W, et al. "Myosin-Va transports the endoplasmic reticulum into the dendritic spines of Purkinje neurons" Nat Cell Biol. 2011 Jan;13(1):40-8 PMID:21151132 |
| Figure(s): | Fig.1-4 |
| Annotation description: | Fig.1: "Absence of the delayed mGluR1-dependent Ca2+ transient in dl20J/dl20J PN spines and hypothetical models for how myosin-Va might function to localize the ER Ca2+ store to spines" Fig.2: "The translocation of ER into spines is disrupted in dl20J/dl20J PNs" Fig.3: "mGFP-myosin-Va expressed in dl20J/dl20J PNs rescues ER targeting and accumulates at the tip of the spine ER" Fig.4: "Myosin-Va is present at the leading tip of the ER tubule as the organelle translocates into a spine" Final implementation: 'establishment of endoplasmic reticulum localization to postsynapse (GO:0099089)' part_of 'regulation of postsynaptic cytosolic calcium levels (GO:0099566)' |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Two-photon microscopy |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 2244 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |