| Annotated protein: | Cortactin-binding protein 2 (CortBP2). Gene symbol: CTTNBP2. Taxonomy: Mus musculus (Mouse). Uniprot ID: B9EJA2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTTNBP2 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | glutamatergic |
| Annotated paper: | Chen YK, et al. "Cortactin-binding protein 2 modulates the mobility of cortactin and regulates dendritic spine formation and maintenance" J Neurosci. 2012 Jan 18;32(3):1043-55 PMID:22262902 |
| Figure(s): | Figure 3 |
| Annotation description: | CTTNBP2 interacts with the actin-binding protein cortactin (CTTN; SynGo ID 223) and is localized in dendritic spines, co-localizing with PSD-95 and F-actin. 9/3/2017 Pim: -literal; "Together, these immunofluorescence experiments identified the synaptic distribution of CTTNBP2 in cultured neurons and mouse brains and suggested an association of CTTNBP2 with actin cytoskeletons." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 224 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |