| Annotated protein: | Ras-related protein Rab-8A (EC 3.6.5.2). Gene symbol: RAB8A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35280 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB8A |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Brown TC, et al. "Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation" J Neurosci. 2007 Nov 28;27(48):13311-5 PMID:18045925 |
| Figure(s): | Fig.1, 2 |
| Annotation description: | Fig.1: "Rab8 and Rab11 are strictly required for LTP." Overexpression of Rab11dn prevents induction of LTP but does not alter basal synaptic transmission. Fig.2: "Rab8 and Rab11 mediate separate anatomical steps in the synaptic delivery of AMPA receptors" Note: The endosomal element of the annotation was based on author intent; Rab11 is a marker protein of the early endosomal compartment and is a well known regulator of endosomal trafficking. The Rab8 protein is postulated to act in a transport step after Rab11 (early endosome). As such the Rab8 function is also part of the endosome-to-plasma membrane transport pathway: "Specifically, these data suggest that GluR1 is sequentially transported through Rab11-driven endosomes for its regulated translocation from dendrites into spines and then through Rab8-driven compartments for its functional insertion into synaptic membranes." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 2235 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |