| Annotated protein: | Src substrate cortactin. Gene symbol: CTTN. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q66HL2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CTTN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Racz B, et al. "The subcellular organization of cortactin in hippocampus" J Neurosci. 2004 Nov 17;24(46):10310-7 PMID:15548644 |
| Figure(s): | Figures 1 - 6 |
| Annotation description: | Using a validated antibody this paper describes that cortactin, a protein implicated in actin nucleation and branching, is expressed in hippocampal CA1 neurons and is enriched in dendritic spines. Here it concentrates in the core of the spine. Together with evidence that cortactin binds F-actin through its amino-terminal acidic region (see e.g. PMID 11018051) and that removal of this domain abrogates spine targeting (PMID 14684878), suggests that cortactin is enriched in spines by binding to F-actin. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| Additional literature: | Cortactin binds F-actin through its amino-terminal acidic region. @ PMID:11018051 Removal of amino-terminal acidic region of Cortactin abrogates spine targeting. @ PMID:14684878 |
| SynGO annotation ID: | 223 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |