| Annotated protein: | Stau1 protein. Gene symbol: STAU1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9ESY8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ STAU1 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic structure (GO:0099010) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Lebeau G, et al. "mRNA binding protein staufen 1-dependent regulation of pyramidal cell spine morphology via NMDA receptor-mediated synaptic plasticity" Mol Brain. 2011 Jun 2;4:22 PMID:21635779 |
| Figure(s): | Fig.1, 2 |
| Annotation description: | Fig.1: "Spine changes induced by Stau1 siRNA are prevented by NMDA receptor blockade and high Mg2+" Fig.2: "Impairment of FSK-induced L-LTP after Stau1 knockdown during high Mg2+ treatment" Together: mRNA binding/transporting protein Stau1 regulates spine morphology and late-LTP induction. The role in late-LTP induction is independent of the role in morphological changes. Literal: "In conclusion, we found that Stau1 involvement in spine morphogenesis is dependent on NMDA receptor-mediated plasticity in hippocampal pyramidal cells. We also found that Stau1 is required for late-LTP, independently of its role in spine morphogenesis" Note: the role as mRNA binding/transporting protein is not shown in this paper. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2229 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |