| Annotated protein: | Leucine-rich repeat-containing protein 7 (Densin-180) (Densin) (Protein LAP1). Gene symbol: LRRC7. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P70587 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC7 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Apperson ML, et al. "Characterization of densin-180, a new brain-specific synaptic protein of the O-sialoglycoprotein family" J Neurosci. 1996 Nov 1;16(21):6839-52 PMID:8824323 |
| Figure(s): | fig 4A, 8 |
| Annotation description: | LRRC7/Densin-180 was enriched in postsynaptic density fractions. 16/01/2018 Pim - Fig.8: "Immunocytochemical localization of densin-180 at synapses in dissociated hippocampal neurons" This figure shows that LRRC7; Densin-180 is co-localized with PSD-95 and Synapsin-I. - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2222 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |