| Annotated protein: | Leucine-rich repeat-containing protein 4B (Netrin-G3 ligand) (NGL-3). Gene symbol: LRRC4B. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0CC10 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4B |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | brain |
| Annotated paper: | Woo J, et al. "Trans-synaptic adhesion between NGL-3 and LAR regulates the formation of excitatory synapses" Nat Neurosci. 2009 Apr;12(4):428-37 PMID:19252495 |
| Figure(s): | fig 2E |
| Annotation description: | LRRC4b was enriched in postsynaptic density fractions. 15/01/2018 Pim - Postsynaptic (as opposed to presynatic) localization of the LRRC4b protein is evidenced by the experiments in Fig.4 that show "Direct aggregation of NGL-3 on the surface of dendrites induces coclustering of excitatory postsynaptic proteins." and the known interaction of NGL-3 with PSD-95 (see additional literature). - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | Indentifies LRRC4b/NGL-3 as a PSD-95 interacting protein. @ PMID:16980967 |
| SynGO annotation ID: | 2220 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |