| Annotated protein: | Filamin-A-interacting protein 1 (FILIP). Gene symbol: FILIP1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q8K4T4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FILIP1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic actin cytoskeleton (GO:0098871) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Yagi H, et al. "Filamin A-interacting protein (FILIP) is a region-specific modulator of myosin 2b and controls spine morphology and NMDA receptor accumulation" Sci Rep. 2014 Sep 15;4:6353 PMID:25220605 |
| Figure(s): | Figure 3 |
| Annotation description: | This paper describes that "exogenous FILIP localised to dendritic spines and dendrites of primary cultured hippocampal neurons." 12/6/2017 Pim Inference of actin cytoskeleton term: "1) FILIP1 has been identified as an interactor of the actin-crosslinking protein Filamin A, see Fig 3 in PMID 12055638. In COS7 cells GFP-tagged FILIP1 shows a fibre-like distribution and co-localizes with phalloidin staining of filamentous actin (Fig 2 in PMID 12055638). Deletion of the Filamin-interaction portion of FILIP disrupts this distribution, indicating that FILIP1 can interact with the actin cytoskeleton via Filamin A. Given the similar distribution of FILIP1 and Filamin A in neurons, both enriched in spines, it is highly likely that also in neuronal spines, FILIP1 is bound to actin through Filamin A." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| Additional literature: | FILIP1 has been identified as an interactor of the actin-crosslinking protein Filamin A (Fig 3) @ PMID:12055638 In COS7 cells GFP-tagged FILIP1 shows a fibre-like distribution and co-localizes with phalloidin staining of filamentous actin (Fig 2 in PMID 12055638). @ PMID:12055638 |
| SynGO annotation ID: | 222 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |