| Annotated protein: | Leucine-rich repeat-containing protein 4 (Brain tumor-associated protein MBAG1) (Netrin-G2 ligand) (NGL-2). Gene symbol: LRRC4. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99PH1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRRC4 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Matsukawa H, et al. "Netrin-G/NGL complexes encode functional synaptic diversification" J Neurosci. 2014 Nov 19;34(47):15779-92 PMID:25411505 |
| Figure(s): | fig 1E |
| Annotation description: | Immunoparticles for LRRC4 were mostly detected postsynaptically in the vicinity of the postsynaptic density of dendritic spines in SR. 2/1/2018 Pim - LRRC4 is referred to as NGL2 in this paper. - Literal: "Immunoparticles for NGL1 and NGL2 were mostly detected postsynaptically in the vicinity of the postsynaptic density of dendritic spines in SLM and SR, respectively." Note: 'SR' means 'CA1 stratum radiatum' - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2219 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |