| Annotated protein: | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12). Gene symbol: RHOA. Taxonomy: Homo sapiens (Human). Uniprot ID: P61586 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RHOA |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Raynaud F, et al. "Rho-GTPase-activating protein interacting with Cdc-42-interacting protein 4 homolog 2 (Rich2): a new Ras-related C3 botulinum toxin substrate 1 (Rac1) GTPase-activating protein that controls dendritic spine morphogenesis" J Biol Chem. 2014 Jan 31;289(5):2600-9 PMID:24352656 |
| Figure(s): | Fig.3 |
| Annotation description: | Local activation GTPase shown with OE of mEGFP-tagged RHOA (FRET assay with Raichu probes). Fig.3: "Rich2 selectively regulates Rac1" Although not regulated by Rich2, presence of activated RhoA can be seen in the heads of dendritic spines. - Literal: "Conversely, the signals obtained with either pRAICHU-RhoA and pRAICHU-Cdc42 were unchanged by the modifications of Rich2 expression (Fig. 3, D and E)." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| SynGO annotation ID: | 2217 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |