| Annotated protein: | Leucine-rich repeat and fibronectin type III domain-containing protein 1 (Synaptic adhesion-like molecule 2). Gene symbol: LRFN1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P0C7J6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Ko J, et al. "SALM synaptic cell adhesion-like molecules regulate the differentiation of excitatory synapses" Neuron. 2006 Apr 20;50(2):233-45 PMID:16630835 |
| Figure(s): | fig 2G, 3 |
| Annotation description: | LRFN1 was enriched in postsynaptic density fractions. 15/01/2018 Pim - Fig.3: "SALM2 Colocalizes and Associates with PSD-95 at Excitatory Synapses" - Based on the known transmembrane topology of the protein, the "integral component of ... membrane" term was chosen. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) IP + WB/MSMS Y2H |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2213 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |