| Annotated protein: | Integrin beta-1 (Fibronectin receptor subunit beta) (VLA-4 subunit beta) (CD antigen CD29). Gene symbol: ITGB1. Taxonomy: Mus musculus (Mouse). Uniprot ID: P09055 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ITGB1 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of synaptic membrane (GO:0099699) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Shi Y, et al. "Integrins control dendritic spine plasticity in hippocampal neurons through NMDA receptor and Ca2+/calmodulin-dependent protein kinase II-mediated actin reorganization" J Neurosci. 2006 Feb 8;26(6):1813-22 PMID:16467530 |
| Figure(s): | fig 1f |
| Annotation description: | ITGB1 was localized in synapses of hippocampal neurons. 16/01/2018 Pim - The experimental data in Fig.1f does not resolve the plasma membrane of the synapse. The localization of ITGB1 to the plasma membrane is inferred from the known membrane localization of the protein and the effectiveness of extracellular inhibitors of ITGB1 that perturbe actin-dynamics in the dendritic spine (only possible when the ITGB1 is TM-plasma membrane protein). |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2211 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |