| Annotated protein: | Neurofilament heavy polypeptide (NF-H) (200 kDa neurofilament protein) (Neurofilament triplet H protein). Gene symbol: NEFH. Taxonomy: Mus musculus (Mouse). Uniprot ID: P19246 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NEFH |
| Ontology domain: | Biological Process |
| SynGO term: | structural constituent of postsynaptic intermediate filament cytoskeleton (GO:0099184) |
| Synapse type(s): | Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Yuan A, et al. "Neurofilament subunits are integral components of synapses and modulate neurotransmission and behavior in vivo" Mol Psychiatry. 2015 Aug;20(8):986-94 PMID:25869803 |
| Figure(s): | Fig 3 |
| Annotation description: | Authors do not address the specific role of alpha-internexin but of neurofilaments, which are heteropolimers made up of NFL, NFM, NFH and alpha-internexin. They investigate the role of neurofilaments by creating a triple knockout mouse by knocking out alpha-internexin, NFH and NFL and address the role of these proteins in synaptic transmission. Tetanic stimulation of Schaffer-collateral pathway in slices induced LTP of fEPSPs in control but not knockout conditions, which suggest a role of these protein in synaptic transmission. Although this is not a direct confirmation of the function of alpha-internexin, the function of this protein is redundant with the function of neurofilaments. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Maria Andres-Alonso (ORCID:0000-0002-1585-539X) Michael Kreutz (ORCID:0000-0003-0575-6950) |
| Lab: | RG Neuroplasticity, Leibniz Institute for Neurobiology, 39118 Magdeburg, Germany and Leibniz Group 'Dendritic Organelles and Synaptic Function', Center for Molecular Neurobiology, ZMNH, University MC, Hamburg-Eppendorf, Hamburg, 20251, Germany |
| SynGO annotation ID: | 2203 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |