| Annotated protein: | CPG2 protein. Gene symbol: SYNE1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63128 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNE1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endocytic zone (GO:0098843) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Cottrell JR, et al. "CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors" Neuron. 2004 Nov 18;44(4):677-90 PMID:15541315 |
| Figure(s): | figure 3, 4 |
| Annotation description: | Fig.3: "Thus, the immunoEM confirms the immunofluorescence data and demonstrates that in vivo CPG2 is concentrated in the postsynaptic site of excitatory synapses and is localized to a distinct synaptic subdomain, lateral to and beneath the PSD." Fig.4: "Thus, the immunoEM staining pattern is consistent with our immunofluorescence finding that CPG2 is colocalized with clathrin in the postsynaptic endocytic zone and suggests that it may be involved in the endocytosis of glutamate receptors." |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2200 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |