| Annotated protein: | LD30122p (VAMP-associated protein 33kDa, isoform B) (VAMP-associated protein 33kDa, isoform C) (VAMP-associated protein 33kDa, isoform E). Gene symbol: VAP33. Taxonomy: Drosophila melanogaster (Fruit fly). Uniprot ID: Q9W4N8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ VAPA SynGO data @ VAPB |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic cytoskeleton (GO:0099569) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Pennetta G, et al. "Drosophila VAP-33A directs bouton formation at neuromuscular junctions in a dosage-dependent manner" Neuron. 2002 Jul 18;35(2):291-306 PMID:12160747 |
| Figure(s): | fig 2, fig4 |
| Annotation description: | DVAP-33A, is localized to neuromuscular junctions where it localises to both the pre- and postsynaptic compartments of the NMJ. Immunogold Labeling Reveals Membrane and Microtubular Association of DVAP-33A. DVAP-33A Associates with Microtubules In Vitro. Loss of DVAP-33A Causes Fewer but Larger Boutons at NMJs. Mutations in DVAP-33A Affect the Synaptic Microtubule Cytoskeleton. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Confocal |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 22 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |