| Annotated protein: | Adaptor related protein complex 3 subunit delta 1. Gene symbol: AP3D1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B5DFK6 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP3D1 |
| Ontology domain: | Biological Process |
| SynGO term: | synaptic vesicle budding from endosome (GO:0016182) |
| Synapse type(s): | cerebellum |
| Annotated paper: | Cheung G, et al. "Adaptor protein complexes 1 and 3 are essential for generation of synaptic vesicles from activity-dependent bulk endosomes" J Neurosci. 2012 Apr 25;32(17):6014-23 PMID:22539861 |
| Figure(s): | fig 4,6,7 |
| Annotation description: | fig4:reserve pool replenishment inhibited. fig6:exocytosis not affected. fig7:bulk endocytosis not affected. rat primary neuronal cultures, rat cerebellar granule neurons. Antibody Anti-AP-1-gamma from BD Biosciences. 11/12/2017 Pim The AP-3D shRNA's (ACAAAGTGTTCCTCAAGTA, CTATCATCCTGGAGAATCA) were traced back to rat Ap3d1 gene via blast analysis. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | fig4/7 @ PMID:24006255 |
| SynGO annotation ID: | 2198 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |