| Annotated protein: | Unconventional myosin-Va (Dilute myosin heavy chain, non-muscle). Gene symbol: MYO5A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9QYF3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ MYO5A |
| Ontology domain: | Biological Process |
| SynGO term: | transport |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Sui WH, et al. "Myosin Va mediates BDNF-induced postendocytic recycling of full-length TrkB and its translocation into dendritic spines" J Cell Sci. 2015 Mar 15;128(6):1108-22 PMID:25632160 |
| Figure(s): | Fig.4, 7, 8 |
| Annotation description: | Fig.4: "Myo5a mediates the postendocytic recycling of TrkB-FL but not TrkB.T1" [shRNA, overexpression] Fig.7: "Inhibiting the association between Myo5a and TrkB by TAT-5aExonE55-66 reduces the recycling of TrkB-FL" [TAT peptide of Myo5a domain --> overexopression] Fig.8: "Myo5a mediates the postendocytic recycling of TrkB-FL and contributes to the BDNF-triggered translocation of TrkB-FL into dendritic spines and sustained downstream signaling" [TAT peptide of Myo5a domain --> overexpression] |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2197 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |