| Annotated protein: | PH and SEC7 domain-containing protein 1 (Exchange factor for ADP-ribosylation factor guanine nucleotide factor 6) (Exchange factor for ARF6) (Exchange factor for ARF6 A) (Pleckstrin homology and SEC7 domain-containing protein 1). Gene symbol: PSD. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5DTT2 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ PSD |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density, intracellular component (GO:0099092) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Fukaya M, et al. "EFA6A, a guanine nucleotide exchange factor for Arf6, interacts with sorting nexin-1 and regulates neurite outgrowth" J Neurochem. 2014 Apr;129(1):21-36 PMID:24261326 |
| Figure(s): | fig 5, fig 6 |
| Annotation description: | EFA6A was enriched in postsynaptic density fractions. EFA6A was localized in dendrites and dendritic spines. Immunogold particles for EFA6A were deposited preferentially on the post-synaptic side and distributed inside and near the PSD in the dendritic spine, with the highest density located between 60 and 90 nm from the post-synaptic plasma membrane. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | This study found that EFA6A is enriched in rat postsynaptic density fractions. @ PMID:16672654 |
| SynGO annotation ID: | 2196 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |