Annotated protein:	Diacylglycerol kinase beta (DAG kinase beta) (EC 2.7.1.107) (90 kDa diacylglycerol kinase) (Diglyceride kinase beta) (DGK-beta). Gene symbol: DGKB. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P49621
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SynGO gene info:	SynGO data @ DGKB
Ontology domain:	Cellular Component
SynGO term:	extrinsic component of postsynaptic density membrane (GO:0099147)
Synapse type(s):	striatum, glutamatergic
Annotated paper:	Hozumi Y, et al. "Diacylglycerol kinase beta accumulates on the perisynaptic site of medium spiny neurons in the striatum" Eur J Neurosci. 2008 Dec;28(12):2409-22 PMID:19087171
Figure(s):	fig 4+5, fig 7
Annotation description:	DGKB was enriched in postsynaptic density fractions. DGKB was localized in cell bodies, dendrites, and dendritic spines. 26/01/2018 Pim Authors note: - "Most of the metal particles (arrowheads) are deposited in association with the cytoplasmic face of the plasma membrane in dendrites (A-C), spines (B) and soma (C)" - "At both types of synapses, immunogold particles for DGKβ were frequently observed at perisynaptic sites (Fig. 6F and G), thus revealing that DGKβ preferentially accumulates on the perisynaptic membrane at corticostriatal and thalamostriatal synapses." Note: With 'perisynaptic' the authors mean that DGKB is localized at the edge of the PSD. The biochemical data in Fig.7 suggest PSD association.
Evidence tracking, Biological System:	Intact tissue
Evidence tracking, Protein Targeting:	Antibody (detection)
Evidence tracking, Experiment Assay:	Electron Microscopy Western blot Biochemical fractionation (generic)
Annotator(s):	Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:	Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:	2195
Dataset release (version):	20231201
View annotation as GO-CAM model: