| Annotated protein: | Diacylglycerol kinase iota (DAG kinase iota) (EC 2.7.1.107). Gene symbol: DGKI. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1MAB7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DGKI |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic density membrane (GO:0099147) |
| Synapse type(s): | hippocampus, glutamatergic cerebellum, glutamatergic |
| Annotated paper: | Yang J, et al. "DGKiota regulates presynaptic release during mGluR-dependent LTD" EMBO J. 2011 Jan 5;30(1):165-80 PMID:21119615 |
| Figure(s): | fig 2E, fig 3 |
| Annotation description: | DGKI was enriched in postsynaptic density fractions. DGKI was localized in cell bodies, dendrites, dendritic spines, and axon terminals. 26/01/2018 Pim Authors state: - "In the cerebellar Purkinje and molecular layers, DGKι signals were detected in cell bodies, dendritic spines, and axon terminals (Figure 3E-G). " - "Quantitative analysis indicated that DGKι signals are present in 13.3±2.5% of axon terminals and 44.2±4.0% of dendritic spines in the hippocampal CA1 region (n=3 animals for wild type (WT) and knockout (KO); total area analysed, 232.2 μm2/animal). " |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| SynGO annotation ID: | 2194 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |