Annotated protein:Diacylglycerol kinase iota (DAG kinase iota) (EC 2.7.1.107). Gene symbol: DGKI. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1MAB7
antibody wiki:
SynGO gene info:SynGO data @ DGKI
Ontology domain:Cellular Component
SynGO term:extrinsic component of postsynaptic density membrane (GO:0099147)
Synapse type(s):hippocampus, glutamatergic
cerebellum, glutamatergic
Annotated paper:Yang J, et al. "DGKiota regulates presynaptic release during mGluR-dependent LTD" EMBO J. 2011 Jan 5;30(1):165-80 PMID:21119615
Figure(s):fig 2E, fig 3
Annotation description:DGKI was enriched in postsynaptic density fractions.
DGKI was localized in cell bodies, dendrites, dendritic spines, and axon terminals.

26/01/2018 Pim
Authors state:
- "In the cerebellar Purkinje and molecular layers, DGKι signals were detected in cell bodies, dendritic spines, and axon terminals (Figure 3E-G). "
- "Quantitative analysis indicated that DGKι signals are present in 13.3±2.5% of axon terminals and 44.2±4.0% of dendritic spines in the hippocampal CA1 region (n=3 animals for wild type (WT) and knockout (KO); total area analysed, 232.2 μm2/animal). "
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Electron Microscopy
Western blot
Biochemical fractionation (generic)
Annotator(s):Hwajin Jung (ORCID:0000-0001-6194-9648)
Eunjoon Kim (ORCID:0000-0001-5518-6584)
Lab:Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea
SynGO annotation ID:2194
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology