| Annotated protein: | Leucine-rich repeat and fibronectin type-III domain-containing protein 3 (Synaptic adhesion-like molecule 4). Gene symbol: LRFN3. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: B0BNK7 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ LRFN3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | brain |
| Annotated paper: | Lie E, et al. "SALM4 suppresses excitatory synapse development by cis-inhibiting trans-synaptic SALM3-LAR adhesion" Nat Commun. 2016 Aug 2;7:12328 PMID:27480238 |
| Figure(s): | fig 1f |
| Annotation description: | LRFN3 was enriched in postsynaptic density fractions. 15/01/2018 Pim - LRFN3 displays an interaction with the PSD-95 protein (see Additional literature) |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hwajin Jung (ORCID:0000-0001-6194-9648) Eunjoon Kim (ORCID:0000-0001-5518-6584) |
| Lab: | Center for Synaptic Brain Dysfunctions, Institute for Basic Science (IBS) and Department of Biological Sciences, Korea Advanced Institute of Science and Technology (KAIST), Daejeon 34141, South Korea |
| Additional literature: | LRFN3 binds PSD-95: " C-termini of Lrfn1, Lrfn2 and Lrfn4 were bound by PDZ domains of postsynaptic protein PSD95, re-distributing PSD95 to cell periphery where the Lrfn proteins were detected." @ PMID:16828986 |
| SynGO annotation ID: | 2190 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |