| Annotated protein: | Gamma-aminobutyric acid receptor subunit beta-1 (GABA(A) receptor subunit beta-1). Gene symbol: GABRB1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P15431 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRB1 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | thalamus, GABAergic |
| Annotated paper: | Huntsman MM, et al. "Fast IPSCs in rat thalamic reticular nucleus require the GABAA receptor beta1 subunit" J Physiol. 2006 Apr 15;572(Pt 2):459-75 PMID:16469775 |
| Figure(s): | Fig.4-7 |
| Annotation description: | Background: This paper studies neurons of the thalamic reticular nucleus. The authors use a pharmacological and channel properties charaterization approach to show that fast GABAergic IPSCs in RTN neurons are mediated by GABAARs that contain the beta1 subunit. Fig.1: Different populations of RTN neurons are recognized that show fast or slow channel decay kinetics. Fig.4+5: Neurons with fast and slow decay kinetics can be differentiated based on their sensitivity to beta2/3 subunit selective agent loreclezole. Neurons with fast decay kinetics are loreclezole-insensitive and are presumed to have the beta1 subunit. Fig.6: Cells that have fast decay kinetics express the beta1 subunit Fig.7: Cells that express the beta1 subunit have fast decay kinetics Authors conclude that fast GABAergic IPSCs in RTN neurons are mediated by GABAARs that contain the beta1 subunit. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2189 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |