Annotated protein:Noelin (Neuronal olfactomedin-related ER localized protein) (Olfactomedin-1) (Pancortin). Gene symbol: OLFM1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O88998
antibody wiki:
SynGO gene info:SynGO data @ OLFM1
Ontology domain:Cellular Component
SynGO term:extrinsic component of synaptic membrane (GO:0099243)
Synapse type(s):cerebral cortex, glutamatergic
retina, glutamatergic
Annotated paper:Sultana A, et al. "Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice" Exp Neurol. 2014 Nov;261:802-11 PMID:25218043
Figure(s):Figure 6
Annotation description:Olfm1 is a secreted glycoprotein that interacts with GluA2-containing AMPA receptors on synaptic membranes. Biochemical fractionation from adult mouse cortex and retina shows Olfm1 co-purifies with synaptic membrane fractions but not synaptic cytosol in both tissues (Figure 6A). Co-immunoprecipitation experiments from synaptic membranes purified from mouse cortex shows Olfm1 localizes to a protein complex containing Olfm2, GluA2 and PSD-95 (Figure 6D-F).
Evidence tracking, Biological System:Intact tissue
Evidence tracking, Protein Targeting:Antibody (detection)
Evidence tracking, Experiment Assay:Western blot
Biochemical fractionation (generic)
Annotator(s):Hana Goldschmidt (ORCID:0000-0002-5676-366X)
Richard Huganir (ORCID:0000-0001-9783-5183)
Lab:Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA
Additional literature:Figure 6B-C: Olfm1 coIP with GluA1-4 @ PMID:24095980
SynGO annotation ID:2185
Dataset release (version):20231201
View annotation as GO-CAM model:Gene Ontology