| Annotated protein: | Noelin-2 (Olfactomedin-2). Gene symbol: OLFM2. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BM13 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ OLFM2 |
| Ontology domain: | Cellular Component |
| SynGO term: | extrinsic component of postsynaptic density membrane (GO:0099147) |
| Synapse type(s): | cerebral cortex, glutamatergic retina, glutamatergic |
| Annotated paper: | Sultana A, et al. "Deletion of olfactomedin 2 induces changes in the AMPA receptor complex and impairs visual, olfactory, and motor functions in mice" Exp Neurol. 2014 Nov;261:802-11 PMID:25218043 |
| Figure(s): | Figure 6 |
| Annotation description: | Olfm2 is a secretory glycoprotein that interacts with GluA2-containing AMPA receptors on synaptic membranes. Biochemical fractionation from adult mouse cortex and retina shows Olfm2 co-purifies with synaptic membrane fractions but not synaptic cytosol in both tissues (Figure 6A). Co-immunoprecipitation experiments from synaptic membranes purified from mouse cortex shows Olfm2 localizes to a protein complex containing Olfm1, GluA2 and PSD-95 (Figure 6D-F). |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Western blot Biochemical fractionation (generic) |
| Annotator(s): | Hana Goldschmidt (ORCID:0000-0002-5676-366X) Richard Huganir (ORCID:0000-0001-9783-5183) |
| Lab: | Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA and Kavli Neuroscience Discovery Institute, Johns Hopkins University, Baltimore, MD 21205, USA |
| Additional literature: | "Noelins1-3 determine distribution and number of AMPARs in synapses and dendrites" @ PMID:37591201 |
| SynGO annotation ID: | 2182 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |