| Annotated protein: | Filamin A. Gene symbol: FLNA. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: A0A8I5ZV49 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLNA |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynapse (GO:0098794) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Segura I, et al. "The Oxygen Sensor PHD2 Controls Dendritic Spines and Synapses via Modification of Filamin A" Cell Rep. 2016 Mar 22;14(11):2653-67 PMID:26972007 |
| Figure(s): | Figure 4 |
| Annotation description: | from the main text: "Staining of RHNs with a specific anti-FLNA antibody (Figures S7A and S7B) used in conjunction with confocal imaging confirmed that FLNA was detectable in the soma and dendrites and in structures resembling dendritic spines, close to synaptophysin+ clusters (data not shown)." this evidence together with the fact that FLNA is a well-known actin-crosslinking proteins indicates that FLNA is located on the postsynaptic actin cytoskeleton in dendritic spines. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Super resolution |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 218 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |