| Annotated protein: | Gamma-aminobutyric acid receptor subunit alpha-5 (GABA(A) receptor subunit alpha-5). Gene symbol: GABRA5. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P19969 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ GABRA5 |
| Ontology domain: | Biological Process |
| SynGO term: | transmitter-gated ion channel activity involved in regulation of postsynaptic membrane potential (GO:1904315) |
| Synapse type(s): | neocortex, GABAergic |
| Annotated paper: | Ali AB, et al. "Synaptic alpha 5 subunit-containing GABAA receptors mediate IPSPs elicited by dendrite-preferring cells in rat neocortex" Cereb Cortex. 2008 Jun;18(6):1260-71 PMID:17951598 |
| Figure(s): | Fig.4, 5 |
| Annotation description: | Fig.4: "Consistent with the finding that the IPSPs elicited by bitufted dendrite-preferring cells were insensitive to the α1/2/3 subunit-selective agonist, zolpidem (Figs 2C,E and 4Ab), these IPSPs were sensitive to IAalpha5 (1 μM, Fig. 4Ab,Bb,C)" Fig.5: "This indicates a predominantly postsynaptic site for the changes in IPSP amplitude with bath application of zolpidem, IAalpha5, or zinc." |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Pim van Nierop (ORCID:0000-0003-0593-3443) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2179 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |