| Annotated protein: | DmX-like protein 2 (Rabconnectin-3a). Gene symbol: RBCN3A. Taxonomy: Danio rerio (Zebrafish). Uniprot ID: U5U756 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DMXL2 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of proton loading (GO:1901546) |
| Synapse type(s): | cochlea |
| Annotated paper: | Einhorn Z, et al. "Rabconnectin3alpha promotes stable activity of the H+ pump on synaptic vesicles in hair cells" J Neurosci. 2012 Aug 8;32(32):11144-56 PMID:22875945 |
| Figure(s): | Fig.3, Fig4 |
| Annotation description: | Fig.3 These figures use fluorescence based Lysotracker staining of acidic compartments to show reduced acidification in the basal domain of the hair cell enriched in synaptic vesicles. This correlates well with a reduced concentration of the synaptic vesicle vacuolar ATPase responsible for synaptic vesicle acidification in Figure 4. Thus reduced acidification and disrupted organization of the vATPase is consistent with Rabconnectin-3 alpha functionally organizing vesicle acidification |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2178 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |