| Annotated protein: | Synaptosomal-associated protein 47 (SNAP-47) (Synaptosomal-associated 47 kDa protein). Gene symbol: SNAP47. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8R570 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SNAP47 |
| Ontology domain: | Biological Process |
| SynGO term: | exocytic insertion of neurotransmitter receptor to postsynaptic membrane (GO:0098967) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Jurado S, et al. "LTP requires a unique postsynaptic SNARE fusion machinery" Neuron. 2013 Feb 6;77(3):542-58 PMID:23395379 |
| Figure(s): | Fig.5, 6 |
| Annotation description: | Fig.5: "Postsynaptic SNAP-47 KD Impairs LTP without Altering Basal Synaptic Transmission or Constitutive Recycling" Fig.6: "SNARE-Dependent Interaction Is Required for SNAP-47's Role in LTP" Literal: "These findings suggest that SNAP-47 specifically participates in the fusion machinery that is responsible for AMPAR exocytosis during LTP." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Ruud Toonen (ORCID:0000-0002-9900-4233) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2163 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |