| Annotated protein: | AP-3 complex subunit delta-1 (AP-3 complex subunit delta) (Adaptor-related protein complex 3 subunit delta-1) (Delta-adaptin) (mBLVR1). Gene symbol: AP3D1. Taxonomy: Mus musculus (Mouse). Uniprot ID: O54774 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ AP3D1 |
| Ontology domain: | Cellular Component |
| SynGO term: | presynaptic endosome (GO:0098830) |
| Synapse type(s): | neocortex |
| Annotated paper: | Newell-Litwa K, et al. "Roles of BLOC-1 and adaptor protein-3 complexes in cargo sorting to synaptic vesicles" Mol Biol Cell. 2009 Mar;20(5):1441-53 PMID:19144828 |
| Figure(s): | Fig.4 |
| Annotation description: | Fig4. vamp2+vamp7+ap3 co-localize in mouse primary neocortical neurons. Antibody against delta subunit of the AP-3 adaptor complex (SA4). Note: the AP-3 complex location is used as a marker of the endosomal compartment. The study details the co-localization of synaptic vesicle proteins and AP-3 to show that the endosomal compartment is in fact present in the presynapse. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Wide-field fluorescence |
| Annotator(s): | Peter McPherson (ORCID:0000-0001-7806-5662) |
| Lab: | Department of Neurology and Neurosurgery, Montreal Neurological Institute, McGill University, Montreal, QC H3A 2B4, Canada |
| SynGO annotation ID: | 2158 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |