| Annotated protein: | Transforming protein RhoA (EC 3.6.5.2) (Rho cDNA clone 12) (h12). Gene symbol: RHOA. Taxonomy: Homo sapiens (Human). Uniprot ID: P61586 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RHOA |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of modification of postsynaptic actin cytoskeleton (GO:1905274) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Murakoshi H, et al. "Local, persistent activation of Rho GTPases during plasticity of single dendritic spines" Nature. 2011 Apr 7;472(7341):100-4 PMID:21423166 |
| Figure(s): | Fig.1, 3 |
| Annotation description: | Fig.1: "Spatiotemporal dynamics of RhoA activation during long-term structural plasticity induced in single spines" Fig.3: "Spatial profile of RhoA and Cdc42 activities" RhoA becomes activated in dendritic spines upon local glutamate uncaging, and spine becomes enlarged. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Two-photon microscopy |
| Annotator(s): | Momchil Ninov (ORCID:0000-0002-0808-7003) Mahdokht Kohansalnodehi (ORCID:0000-0002-3898-5197) Reinhard Jahn (ORCID:0000-0003-1542-3498) |
| Lab: | Department of Neurobiology, Max Planck Institute for Biophysical Chemistry, 37077 Göttingen, Germany |
| Additional literature: | Changing the balance between G-actin and F-actin in dendritic spine underlies structural plasticity. Rho is not mentioned but shows the substrate of Rho activity, actin cytoskeleton, is involved in spine remodelling. @ PMID:15361876 |
| SynGO annotation ID: | 2147 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |