| Annotated protein: | Kinesin-like protein KIF17 (MmKIF17). Gene symbol: KIF17. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q99PW8 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIF17 |
| Ontology domain: | Biological Process |
| SynGO term: | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Yin X, et al. "Regulation of NMDA receptor transport: a KIF17-cargo binding/releasing underlies synaptic plasticity and memory in vivo" J Neurosci. 2012 Apr 18;32(16):5486-99 PMID:22514311 |
| Figure(s): | Fig.3, 4 |
| Annotation description: | Fig.3: "NMDA-mediated synaptic activity and plasticity in Tg+/kif17-/- mice" KIF17 mutants show defects in LTP induction. These results suggest that mutation of the KIF17 CTD leads to defective NMDA receptor-dependent synaptic activity and plasticity. Fig.4 OE of KIF17 mutants in KIF17 null background showed that GluN2B clusters were much less mobile, traveling anterogradely at a much slower velocity. Fig.6/7 KIF17 mutants show reduced amounts of functional NMDARs on the neuronal surface. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Genetic transformation (eg; knockout, knockin, mutations) |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| Additional literature: | "Experiments with vesicles containingN-methyl-d-aspartate (NMDA) receptor 2B (NR2B subunit) show that they are transported along microtubules by KIF17, a neuron-specific molecular motor in neuronal dendrites. Selective transport is accomplished by direct interaction of the KIF17 tail with a PDZ domain of mLin-10 (Mint1/X11), which is a constituent of a large protein complex including mLin-2 (CASK), mLin-7 (MALS/Velis), and the NR2B subunit." @ PMID:10846156 |
| SynGO annotation ID: | 2144 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |