| Annotated protein: | Kinesin heavy chain isoform 5A (Kinesin heavy chain neuron-specific 1) (Neuronal kinesin heavy chain) (NKHC). Gene symbol: KIF5A. Taxonomy: Mus musculus (Mouse). Uniprot ID: P33175 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ KIF5A |
| Ontology domain: | Biological Process |
| SynGO term: | anterograde dendritic transport of neurotransmitter receptor complex (GO:0098971) |
| Synapse type(s): | brain |
| Annotated paper: | Setou M, et al. "Glutamate-receptor-interacting protein GRIP1 directly steers kinesin to dendrites" Nature. 2002 May 2;417(6884):83-7 PMID:11986669 |
| Figure(s): | Fig.3 |
| Annotation description: | Fig.1/2 GRIP1 acts a KIF5A-binding scaffolding protein for GluR2 in vivo. Fig.3 OE of dom neg KIF5A construct competed with the intrinsic KIF5GRIP1 complex and reduced the amounts of GRIP1 and GluR2 in synapses: "The GFP-KHCCBD construct competed with the intrinsic KIF5-GRIP1 complex (Fig. 3b), and reduced the amounts of GRIP1 (Fig. 3c) and GluR2 in the synapses (Fig. 3e). Control KIF17 tail expression did not abolish GluR2 in the synapses (Fig. 3f)" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Harold MacGillavry (ORCID:0000-0002-6153-3586) Casper Hoogenraad (ORCID:0000-0002-2666-0758) |
| Lab: | Department of Biology, Faculty of Science, Utrecht University, 3584 CH Utrecht, The Netherlands |
| SynGO annotation ID: | 2141 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |