| Annotated protein: | Protein shisa-9 (Cystine-knot AMPAR modulating protein of 44 kDa) (CKAMP44). Gene symbol: SHISA9. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q9CZN4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SHISA9 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic density membrane (GO:0099061) |
| Synapse type(s): | forebrain, glutamatergic hippocampus, glutamatergic |
| Annotated paper: | von Engelhardt J, et al. "CKAMP44: a brain-specific protein attenuating short-term synaptic plasticity in the dentate gyrus" Science. 2010 Mar 19;327(5972):1518-22 PMID:20185686 |
| Figure(s): | fig 2 |
| Annotation description: | shisa9 is highly enriched in PSD subcellular fractions from adult mouse forebrain. Fluorescence microscopy demonstrates postsynaptic co-localization with gria1 and gria2/3 in mouse cultured hippocampal neurons at 20 days in vitro. "integral component" was Inferred from the protein's transmembrane domain. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2137 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |