| Annotated protein: | Diacylglycerol lipase-alpha (DAGL-alpha) (DGL-alpha) (EC 3.1.1.116) (Neural stem cell-derived dendrite regulator) (Sn1-specific diacylglycerol lipase alpha). Gene symbol: DAGLA. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q6WQJ1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ DAGLA |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | striatum |
| Annotated paper: | Jung KM, et al. "Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome" Nat Commun. 2012;3:1080 PMID:23011134 |
| Figure(s): | figure 3 |
| Annotation description: | immuno-EM demonstrates localization in spine head membrane of wild-type mice. integral to membrane localization based on near-membrane location in EM images and the protein having TMM domains. to clarify the terminology used in the paper for the "perisynapse" localization; "Morphological studies have shown that both phospholipase C-β and DGL-α are localized to the perisynapse, a subdivision of the dendritic spine that forms a 100-200-nm-thick border around the postsynaptic density" |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | Figure 4: EM showed preferential distribution of DGLα on dendritic spines and shafts of GCs with the highest accumulation in the spine neck. @ PMID:21613483 |
| SynGO annotation ID: | 2136 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |