| Annotated protein: | Acetylcholinesterase (AChE) (EC 3.1.1.7). Gene symbol: ACHE. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P37136 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ACHE |
| Ontology domain: | Cellular Component |
| SynGO term: | synaptic cleft (GO:0043083) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Blotnick E, et al. "Exercise modulates synaptic acetylcholinesterase at neuromuscular junctions" Neuroscience. 2016 Apr 5;319:221-32 PMID:26820598 |
| Figure(s): | Figure 5 |
| Annotation description: | "Figure 5. Selective increase in AChE content in the synaptic cleft after muscle training." "Conclusion: Overall, our study supports a functional role for the G4 AChE tetramer in the neuromuscular synapse" 11/12/2017 Pim - The authors show that a membrane attached form of AChE is responsible for the increase of ACh-esterase activity in the muscle. The term 'synaptic cleft (GO:0043083)' is selected based on the site of activity of the non-membrane bound variants and the membrane bound variant together. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2130 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |