| Annotated protein: | 43 kDa receptor-associated protein of the synapse (RAPsyn) (43 kDa postsynaptic protein) (Acetylcholine receptor-associated 43 kDa protein). Gene symbol: RAPSN. Taxonomy: Mus musculus (Mouse). Uniprot ID: P12672 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAPSN |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic specialization membrane (GO:0099634) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Chen PJ, et al. "AChRs Are Essential for the Targeting of Rapsyn to the Postsynaptic Membrane of NMJs in Living Mice" J Neurosci. 2016 May 25;36(21):5680-5 PMID:27225759 |
| Figure(s): | figure 1-4 |
| Annotation description: | Co-localizes with acetylcholine receptors (AChRs) in mouse NMJ, fluorescence imaging + fig4. Rabsyn is surface expressed, can be deleted/rescued by mutation of AChR interacting domain in myoblasts. "Altogether, these results strongly suggest that AChRs serve as a mediator for the targeting and association of rapsyn with the postsynaptic membrane at synaptic sites." |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | PMID:7675108 PMID:23056392 |
| SynGO annotation ID: | 2129 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |