| Annotated protein: | Neuronal vesicle trafficking-associated protein 1 (Brain neuron cytoplasmic protein 1/2) (Neuron-enriched endosomal protein of 21 kDa) (Neuron-specific protein family member 1). Gene symbol: NSG1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P02683 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ NSG1 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic endosome (GO:0098845) |
| Synapse type(s): | cerebral cortex, glutamatergic |
| Annotated paper: | Steiner P, et al. "Modulation of receptor cycling by neuron-enriched endosomal protein of 21 kD" J Cell Biol. 2002 Jun 24;157(7):1197-209 PMID:12070131 |
| Figure(s): | figure 4 |
| Annotation description: | Fig.4 NEEP21 localizes to wortmannin-sensitive endosomal compartment cortical neurons: "This shows that NEEP21 localizes to a wortmannin-sensitive endosomal compartment." 11/12/2017 Pim - The endosomal compartment marked by NEEP21 is not show to be spacial associated with synapses in Fig.4 but to reside in the dendritic compartment (Fig.7). In Fig.8 the role of NEEP21 is shown in the endosomal recycling of AMPARs. Therefore the endosomal compartment is admissible as a 'postsynaptic endosome (GO:0098845)' for SynGO. |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2128 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |