| Annotated protein: | Rho GTPase-activating protein 44 (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2). Gene symbol: ARHGAP44. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: F1LQX4 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGAP44 |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic density (GO:0014069) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Raynaud F, et al. "Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation" J Neurosci. 2013 Jun 5;33(23):9699-715 PMID:23739967 |
| Figure(s): | figure 1 |
| Annotation description: | Fig.1F The authors do not mention the postsynaptic density themselves. However, PSD localization is observed by the annotator and referenced to this paper by other authors too (f.i. pmid:26969129) 11/12/2017 Pim - The authors mention interaction with Shank3 (a known constituent of the PSD) and to act on AMPAR recycling. This strengthens the claim on postsynaptic localization. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antibody (detection) |
| Evidence tracking, Experiment Assay: | Electron Microscopy Protein-protein interaction (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2123 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |