| Annotated protein: | Leucine-rich repeat transmembrane protein FLRT3 (Fibronectin leucine rich transmembrane protein 3). Gene symbol: FLRT3. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q8BGT1 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ FLRT3 |
| Ontology domain: | Cellular Component |
| SynGO term: | integral component of postsynaptic membrane (GO:0099055) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | O'Sullivan ML, et al. "FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development" Neuron. 2012 Mar 8;73(5):903-10 PMID:22405201 |
| Figure(s): | figure 2 |
| Annotation description: | "FLRT3-myc was found in dendrites in puncta that partially colocalized with glutamatergic but not GABAergic synapses (Figure 2C and S2C). Together, these results suggest that FLRT3 is a postsynaptic protein of glutamatergic synapses." figure 2c; "In dissociated hippocampal neurons, FLRT3-myc (green) localizes to dendrites in a punctate fashion, partially colocalizes with the postsynaptic marker PSD95 (red), and is closely associated with presynaptic VGluT1 puncta (blue)" note; we annotated against "integral component of membrane" as the protein has a TMM (protein name; Leucine-rich repeat transmembrane protein FLRT3). |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons Non-neuronal tissue |
| Evidence tracking, Protein Targeting: | Over-expression Antibody (detection) |
| Evidence tracking, Experiment Assay: | Confocal Western blot Biochemical fractionation (generic) |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2120 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |