| Annotated protein: | CPG2 protein. Gene symbol: SYNE1. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63128 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ SYNE1 |
| Ontology domain: | Biological Process |
| SynGO term: | regulation of postsynaptic neurotransmitter receptor endocytosis (GO:0099149) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Cottrell JR, et al. "CPG2: a brain- and synapse-specific protein that regulates the endocytosis of glutamate receptors" Neuron. 2004 Nov 18;44(4):677-90 PMID:15541315 |
| Figure(s): | figure 6,7 |
| Annotation description: | figure 6; CPG2 Knockdown Disrupts Constitutive Glutamate Receptor Internalization figure 7; CPG2 Knockdown Disrupts Activity-Induced Internalization of AMPA Receptors |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Electron Microscopy Wide-field fluorescence Western blot |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| Additional literature: | See Fig.6 and 7 @ PMID:24191017 See also this ref. @ PMID:26776730 |
| SynGO annotation ID: | 2116 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |