| Annotated protein: | Activity-regulated cytoskeleton-associated protein (Activity-regulated gene 3.1 protein) (ARC/ARG3.1) (Arg3.1). Gene symbol: ARC. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q63053 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARC |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Messaoudi E, et al. "Sustained Arc/Arg3.1 synthesis controls long-term potentiation consolidation through regulation of local actin polymerization in the dentate gyrus in vivo" J Neurosci. 2007 Sep 26;27(39):10445-55 PMID:17898216 |
| Figure(s): | figure 2, 3 |
| Annotation description: | Figure 2: Arc antisense infusion 2 h after high-frequency stimulation blocks LTP consolidation. 11/12/2017 Pim - Contrary to the claim of the authors I have not annotated the claimed role of Arc in the regulation of actin dynamics. Reason is that I do not see that this is a direct or a indirect mechanism of action for the Arc protein. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | RNAi / shRNA |
| Evidence tracking, Experiment Assay: | Whole-cell patch clamp |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2113 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |