| Annotated protein: | Rho GTPase-activating protein 44 (Rho-type GTPase-activating protein RICH2) (RhoGAP interacting with CIP4 homologs protein 2) (RICH-2). Gene symbol: ARHGAP44. Taxonomy: Mus musculus (Mouse). Uniprot ID: Q5SSM3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ARHGAP44 |
| Ontology domain: | Biological Process |
| SynGO term: | modification of postsynaptic structure (GO:0099010) |
| Synapse type(s): | hippocampus |
| Annotated paper: | Raynaud F, et al. "Shank3-Rich2 interaction regulates AMPA receptor recycling and synaptic long-term potentiation" J Neurosci. 2013 Jun 5;33(23):9699-715 PMID:23739967 |
| Figure(s): | figure 4,5,7 |
| Annotation description: | Fig.4/5; Rich2 activity is needed for spine enlargement induced by chemical LTP and increase of synaptic currents, and increase of surface levels of synaptic AMPARs [fixed tissue] (NMDAR activation)[Rich2 KD, OE Rich2 mutant proteins] Fig.7; Rich2 interaction with Shank3 is needed for cLTP induced exocytosis of GluR1, spine enlargement |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2110 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |