| Annotated protein: | Acetylcholinesterase (AChE) (EC 3.1.1.7). Gene symbol: ACHE. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P37136 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ ACHE |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter catabolic process (GO:0042135) |
| Synapse type(s): | Neuro-muscular junction |
| Annotated paper: | Blotnick E, et al. "Exercise modulates synaptic acetylcholinesterase at neuromuscular junctions" Neuroscience. 2016 Apr 5;319:221-32 PMID:26820598 |
| Figure(s): | Fig.3-5, Table 3 |
| Annotation description: | Localized in synaptic cleft (Fig.3-5), has activity to breakdown ACh (Table 3). 11/12/2017 Pim - The authors make the case that the "amphiphilic (membrane-anchored) G4 AChE...which is attached to the membrane by hydrophobic non-catalytic subunit called PRiMA (proline-rich membrane anchor)" arrangement of AChE is responsible for the elevated AChE activity observed in muscles after exercise. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | none of the above |
| Evidence tracking, Experiment Assay: | Enzyme assay |
| Annotator(s): | Frank Koopmans (ORCID:0000-0002-4973-5732) Guus Smit (ORCID:0000-0002-2286-1587) Matthijs Verhage (ORCID:0000-0002-2514-0216) |
| Lab: | Department of Functional Genomics, Department of Molecular and Cellular Neurobiology, Center for Neurogenomics and Cognitive Research, Vrije Universiteit Amsterdam, 1081 HV Amsterdam, The Netherlands |
| SynGO annotation ID: | 2109 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |