| Annotated protein: | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (YL8). Gene symbol: RAB11A. Taxonomy: Homo sapiens (Human). Uniprot ID: P62491 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB11A |
| Ontology domain: | Cellular Component |
| SynGO term: | postsynaptic recycling endosome (GO:0098837) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Esteves da Silva M, et al. "Positioning of AMPA Receptor-Containing Endosomes Regulates Synapse Architecture" Cell Rep. 2015 Nov 3;13(5):933-43 PMID:26565907 |
| Figure(s): | Fig.2 |
| Annotation description: | Fig.2: "Recycling Endosome Transport into Dendritic Spines Depends Actin and on MT Dynamics" - Literal: "We frequently observed Rab11 vesicles containing GFP-GluA2 in dendritic spines (Figure 2A; Movie S2). Under basal conditions, GFP-GluA2-positive Rab11 vesicles moved in and out of spines (Figures 2B and S2A). The recycling endosomes that entered spines did not necessarily emerge from immobile storage sites near the spine base, but frequently moved from distant dendritic regions" |
| Evidence tracking, Biological System: | Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| Additional literature: | PMID:22685325 |
| SynGO annotation ID: | 2102 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |