| Annotated protein: | Ras-related protein Rab-11A (Rab-11) (EC 3.6.5.2) (24KG). Gene symbol: RAB11A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P62494 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB11A |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor transport, endosome to postsynaptic membrane (GO:0098887) |
| Synapse type(s): | hippocampus, glutamatergic Schaffer collateral synapse (CA3->CA1) |
| Annotated paper: | Brown TC, et al. "Functional compartmentalization of endosomal trafficking for the synaptic delivery of AMPA receptors during long-term potentiation" J Neurosci. 2007 Nov 28;27(48):13311-5 PMID:18045925 |
| Figure(s): | Figs 1, 2 |
| Annotation description: | Overexpression of dominant negative Rab11 decreases surface GluR1 levels (Fig 2) thereby abolishing potentiation in a LTP paradigm (Fig 1). ---------------- Fig.1: "Rab8 and Rab11 are strictly required for LTP." Overexpression of Rab11dn prevents induction of LTP but does not alter basal synaptic transmission. Fig.2: "Rab8 and Rab11 mediate separate anatomical steps in the synaptic delivery of AMPA receptors" Note: The endosomal element of the annotation was based on author intent; Rab11 is a marker protein of the early endosomal compartment and is a well known regulator of endosomal trafficking. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Field recordings |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| Additional literature: | Live imaging of Rab11 and GluR2 indicates an increase in surface levels of GluR2 following entry and exocytosis of Rab11+ vesicles in dendritic spines (Fig 1). @ PMID:26565907 |
| SynGO annotation ID: | 2099 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |