| Annotated protein: | Ras-related protein Rab-8A (EC 3.6.5.2). Gene symbol: RAB8A. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: P35280 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ RAB8A |
| Ontology domain: | Biological Process |
| SynGO term: | neurotransmitter receptor transport to postsynaptic membrane (GO:0098969) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Gerges NZ, et al. "Local control of AMPA receptor trafficking at the postsynaptic terminal by a small GTPase of the Rab family" J Biol Chem. 2004 Oct 15;279(42):43870-8 PMID:15297461 |
| Figure(s): | Fig.1, 3-7 |
| Annotation description: | Over-expresison of dominant negative Rab8 decreases AMPAR currents (Fig 1) and surface levels of GluR2 (Figure 4) by regulating both basal as well as activity dependent synaptic insertion of AMPARs (Figs 5 and 7). --------------- Note: The cellular location of rab8 in synapses in unknown and might include the TGN or recycling endosomes (see model in Fig.8). Neither of these routes is detailed in the experiments. As a result, the selected term does not mention a source cellular compartment involved in the NTR trafficking event. |
| Evidence tracking, Biological System: | Intact tissue Cultured neurons |
| Evidence tracking, Protein Targeting: | Over-expression |
| Evidence tracking, Experiment Assay: | Confocal Whole-cell patch clamp |
| Annotator(s): | John Chua (ORCID:0000-0002-5615-1014) |
| Lab: | Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Neurobiology/Ageing Program, Life Sciences Institute, National University of Singapore and Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Singapore |
| SynGO annotation ID: | 2098 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |