| Annotated protein: | Cadherin-2 (Neural cadherin) (N-cadherin) (CD antigen CD325). Gene symbol: CDH2. Taxonomy: Rattus norvegicus (Rat). Uniprot ID: Q9Z1Y3 |
| antibody wiki: | |
| SynGO gene info: | SynGO data @ CDH2 |
| Ontology domain: | Biological Process |
| SynGO term: | modulation of chemical synaptic transmission (GO:0050804) |
| Synapse type(s): | hippocampus, glutamatergic |
| Annotated paper: | Tang L, et al. "A role for the cadherin family of cell adhesion molecules in hippocampal long-term potentiation" Neuron. 1998 Jun;20(6):1165-75 PMID:9655504 |
| Figure(s): | Fig.4, 6 |
| Annotation description: | Fig.6-8 The use of HAV peptides were shown by the authors to disrupt the homophilic interactions between specific cadherin subtypes. Infusion of N-cad HAV peptides does not alter basal synaptic signal transduction, but interferes with LTP induction (not maintenance) with different protocols. N-cad HAV peptides do not interfere with PPI, NMDAR EPSPs or postsynaptic depolarization mechanisms. |
| Evidence tracking, Biological System: | Intact tissue |
| Evidence tracking, Protein Targeting: | Antagonist / agonist |
| Evidence tracking, Experiment Assay: | Field recordings |
| Annotator(s): | Noa Lipstein (ORCID:0000-0002-0755-5899) Cordelia Imig (ORCID:0000-0001-7351-8706) Vincent O'connor (ORCID:0000-0003-3185-5709) Nils Brose (ORCID:0000-0003-0938-8534) |
| Lab: | Department of Molecular Neurobiology, Max Planck Institute of Experimental Medicine, 37075 Göttingen, Germany |
| SynGO annotation ID: | 2097 |
| Dataset release (version): | 20231201 |
| View annotation as GO-CAM model: |  |